Jeff, your query is quite broad. Where do your priorities lie (weight vs. comfort vs. fun toys), what sort of places and conditions are you looking to visit? It all can make a huge difference in gear.
I have similar big pack, an Arcteryx Altra 75, but I only use it for winter hikes requiring a lot of gear, or times when I take a full DSLR rig with tripod and full camping gear. I did a 7 day trip in thr Sierra earlier this year out of a 50L REI Flash, which weighs 3.5lb less. And I love my REI Stoke 29 for sub 20lb loads.