Tom Bihn Smart Alec. It is really light but holds a ton. It is my daily backpack. I have also taken it on many trips. It may hold more than the Synapse 25 because of it's form factor (mostly a very large opening but with some useful pockets and o-rings). Also it is a very good size for short people. I think the Synapse 19 would be too small. I can check that it will hold everything you want if I get time today. I'll be borrowing the RO Mini Ruck from Gene and can take pictures of the two when I get it and tell you which is more comfortable, etc. I am guessing that I will stick with the Smart Alec though. http://www.tombihn.com/PROD/TB0103.html
Also, I realized that it will hold a 13" MBP with 2 water bottles - I don't know what I was thinking.