Thanks for the comments above I do appreciate it since I'm always looking to do better.
I was thinking of putting the transformers in the front, but I couldn't fit the power inlet and output comfortably with the board layout. I can think about this as a future revision. Currently, I've got about a 4" gap between the top of the transformers and bottom of the inputs when the units are stacked, which helps a bit. I've also got about 2" between the transformer and output and I will shield the output cable leading to the output. Transformers are shielded too.
Additionally, I added shielding (tied to chassis/earth on the PS side) between the AC in the umbilical and the DC outputs.
I can look into mu metal / steal as well. This seems like a great solution. What about a steel mesh (just thinking of air flow)?
What's the specific concern on the transistor mounts? I know there are more screws if I want to remove the board, but I did like the idea of saving space and also that there was one less component between the transistor and the sinks. I considered mounting the transistors to a 3/16" flat plate and mounting the plate to the sinks, but it just felt like a lot of extra machining and I didn't have a clear goal for it in mind.
EDIT: One other thought/question. I was going to solder the transformer leads for the filaments directly to the output jack. If I need to replace that transformer for any reason I could simply cut the leads and splice the new transformer in. I don't love this, but it's not that much work in the grand scheme of things just in case the LV transformer blew out in the future.
Are there any good suggestions for in-line connectors? For the output filaments, they'd need to be able to handle the -500V to chassis/input filament isolation. This feels like a bit of over-engineering, but this whole build is about that :)